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Evidence found and GRADE certainty

1,133 questions · 1,153 findings · 36 reviews · Skin

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No studies found 407 · 35.3%GRADE not reported 90 · 7.8%Very low 183 · 15.9%Low 209 · 18.1%Moderate 211 · 18.3%High 53 · 4.6%

Injectable fillers vs placebo or no treatment

Participant‐reported scar improvement (short‐term) N of participants with > 50% improvement in acne scars · people with acne scars

Injectable fillers probably leads to higher participant‐reported scar improvement (short‐term) N of participants… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Fractional laser vs non‐fractional non‐ablative laser

Participant‐assessed adverse events (short‐term) Burning N of participants with adverse events · people with acne scars

It is very uncertain whether fractional laser changes participant‐assessed adverse events (short‐term) Burning N of… compared with non‐fractional non‐ablative laser (very low certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Patient satisfaction Number of satisfied patients · people with acne scars

Injectable fillers probably leads to higher participant satisfaction N of satisfied participants compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Participant‐assessed adverse events (short‐term) N of participants with positive adverse events · people with acne scars

Injectable fillers showed no clear difference in participant‐reported adverse events (short‐term) N of participants… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Investigator‐assessed adverse events (short‐term) N of participants with positive adverse events · people with acne scars

Injectable fillers showed no clear difference in investigator‐assessed adverse events (short‐term) N of participants… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Fractional laser vs radiofrequency

Participant‐reported scar improvement (long‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Fractional laser vs radiofrequency

Participant‐reported scar improvement (short‐term) N of participants with > 50% improvement in acne scars · people with acne scars

It is very uncertain whether fractional laser changes participant‐reported scar improvement (short‐term) N of participants… compared with radiofrequency (very low certainty).

1 finding from 1 review

Fractional laser vs radiofrequency

Investigator‐assessed adverse events (short‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Azelaic acid vs placebo

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Azelaic acid leads to higher participant‐assessed improvement in rosacea severity Marked… compared with placebo (high certainty).

1 finding from 1 review

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in physician‐assessed improvement in rosacea severity Investigator's… compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review