Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to geographic atrophy · people with AMD

Antioxidant multivitamin and mineral supplement showed no clear difference in progression to geographic atrophy compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with AMD

Antioxidant multivitamin and mineral supplement probably leads to lower progression to visual loss (loss of 3 or more lines on logMAR chart) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Lutein with or without zeaxanthin vs placebo

Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo (low certainty).

1 finding from 1 review

Any cranberry product vs placebo or control

Symptomatic, culture‐verified UTI Elderly men and women in institutions · preventing UTI

Any cranberry product showed no clear difference in symptomatic, culture‐verified UTI Elderly men and women in… compared with placebo or control (moderate certainty).

1 finding from 1 review

Any cranberry product vs placebo or control

Symptomatic, culture‐verified UTI Adults with bladder emptying issues or multiple sclerosis · preventing UTI

Any cranberry product showed no clear difference in symptomatic, culture‐verified UTI Adults with bladder emptying… compared with placebo or control (low certainty).

1 finding from 1 review

Any cranberry product vs placebo or control

Symptomatic, culture‐verified UTI People with a susceptibility to a UTI due to an intervention · preventing UTI

Any cranberry product may leads to lower symptomatic, culture‐verified UTI People with a susceptibility to a… compared with placebo or control (low certainty).

1 finding from 1 review

Serenoa repens vs placebo or no intervention

Urologic symptom scores · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens showed no clear difference in urologic symptom scoreMeasured by IPSS scores (range 0 to 35)Higher… compared with placebo or no intervention (high certainty).

1 finding from 1 review

Serenoa repens vs placebo or no intervention

QoL · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens showed no clear difference in quality of lifeMeasured by IPSS‐QoL score (range 0 to 6) compared with placebo or no intervention (high certainty).

1 finding from 1 review

Serenoa repens vs placebo or no intervention

Adverse eventsCumulative incidence · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens showed no clear difference in adverse eventsCumulative incidence compared with placebo or no intervention (moderate certainty).

1 finding from 1 review