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Evidence found and GRADE certainty

1,304 questions · 1,352 findings · 210 reviews

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No studies found 230 · 17%GRADE not reported 163 · 12.1%Very low 269 · 19.9%Low 277 · 20.5%Moderate 291 · 21.5%High 122 · 9%

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Tezepelumab (1 RCT; 56 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in tezepelumab (1 RCT; 56 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Lebrikizumab (1 RCT; 156 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes lebrikizumab (1 RCT; 156 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

PF‐04965842 (1 RCT; 211 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes PF‐04965842 (1 RCT; 211 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Tralokinumab (1 RCT; 153 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes tralokinumab (1 RCT; 153 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Apremilast (1 RCT; 121 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in apremilast (1 RCT; 121 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Baricitinib (1 RCT; 75 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes baricitinib (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 6 RCTsTotal participants: 1720 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

Dupilumab (3 RCTs; 1082 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in dupilumab (3 RCTs; 1082 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Methotrexate (1 RCT; 50 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes methotrexate (1 RCT; 50 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Fezakinumab (1 RCT; 40 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes fezakinumab (1 RCT; 40 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

QGE031 (1 RCT; 10 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes QGE031 (1 RCT; 10 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Cyclosporin A (2 RCTs; 49 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes cyclosporin A (2 RCTs; 49 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 13 RCTsTotal participants: 1658 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

Corticosteroid (1 RCT; 21 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes corticosteroid (1 RCT; 21 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Dupilumab (4 RCTs; 990 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes dupilumab (4 RCTs; 990 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Cyclosporin A (3 RCTs; 74 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes cyclosporin A (3 RCTs; 74 participants) (very low certainty).

1 finding from 1 review