Physician Global Assessment (surface of erosive lesions) · People with erosive oral lichen planus
1% pimecrolimus cream showed no clear difference in physician Global Assessment (surface of erosive lesions) compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review
Pain reduction (VAS 0-100) · People with erosive oral lichen planus
0.1% triamcinolone acetonide in orabase led to higher pain reduction (VAS 0-100) compared with ciclosporin solution; GRADE not reported.
1 finding from 1 review
Relapse rate when medications stopped · People with erosive oral lichen planus
1 finding from 1 review
Topical clobetasol gave less stable results than ciclosporin when therapy ended and showed a higher incidence of side-effects (Conrotto 2006, n=40).
1 study · 40 participants
GRADE not reported
Pain reduction (VAS) · People with erosive oral lichen planus
Topical clobetasol propionate 0.025% showed no clear difference in pain reduction (VAS) compared with topical clobetasol propionate 0.05%; GRADE not reported.
1 finding from 1 review
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Passeron 2007: 1% pimecrolimus well-tolerated, transient burning (2) during the first 2 weeks. Swift 2005: pimecrolimus - slight burning of the tip of the tongue after applying 1% pimecrolimus…
3 studies · 52 participants
GRADE not reported
Physician Global Assessment (strong improvement) · People with erosive oral lichen planus
1% pimecrolimus cream led to higher physician Global Assessment (strong improvement) compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review
Any topical or systemic intervention vs Placebo, no treatment, or another intervention
Outcome not reported · People with erosive anogenital (genital) lichen planus
The review found no eligible studies for this question.
1 finding from 1 review
Participant global self-assessment · People with erosive oral lichen planus
1 finding from 1 review
One study (Passeron 2007) assessed participant global self-assessment on a 5-point scale: 5/6 participants in the 1% pimecrolimus group rated their improvement as moderate or important versus 1/6 in the placebo group…
1 study · 12 participants
GRADE not reported
Eating a normally varied diet · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions
The review found no eligible studies for this question.
1 finding from 1 review
Pain reduction (VAS 0-100) · People with erosive oral lichen planus
1 finding from 1 review
In the Hegarty 2002 cross-over trial (n=22), no statistical testing of the pain score (VAS 0 to 100) was reported; it is not clear whether the difference is statistically significant (fluticasone mean score 19.8 versus…
1 study · 22 participants
GRADE not reported
Physician Global Assessment (clinical signs, complete response) · People with erosive oral lichen planus
Fluocinonide in adhesive base showed no clear difference in physician Global Assessment (clinical signs, complete response) compared with placebo; GRADE not reported.
1 finding from 1 review
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Malhotra 2008: betamethasone oral mini-pulse - transient oedema over the face (7), oedema over hands and feet (4), epigastric discomfort (7), weakness/fatigue (5), loose stools (1), headache…
1 study · 22 participants
GRADE not reported
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Campisi 2004: oral candidiasis (1 in the lipid-loaded microspheres group, 2 in the conventional ointment group). None serious.
1 study · 50 participants
GRADE not reported
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Reduction in target/mean lesion size · People with erosive oral lichen planus
1 finding from 1 review
Restoration of sexual activity · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions
The review found no eligible studies for this question.
1 finding from 1 review
Clinical response ‐ complete response · People with erosive oral lichen planus
1% pimecrolimus cream showed no clear difference in complete clinical response (complete clearance) compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review
Partial response (partial or complete response) · People with erosive oral lichen planus
Topical ciclosporin 1.5% gel led to higher partial response (partial or complete response) compared with topical clobetasol propionate 0.025% gel; GRADE not reported.
1 finding from 1 review
Relapse rate when medications stopped · People with erosive oral lichen planus
1 finding from 1 review
In Passeron 2007 (n=12), all participants who improved during treatment relapsed within 1 month of ceasing treatment.
1 study · 12 participants
GRADE not reported
Physician Global Assessment (cure of erosive lesions, remarkably effective) · People with erosive oral lichen planus
Radix tripterygium hypoglaucum tablet (THT) showed no clear difference in physician Global Assessment (cure of erosive lesions, remarkably… compared with tripterygium glucosides tablet (TGT); GRADE not reported.
2 findings from 1 review