What do systematic reviews say?

Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline

It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes periodontal healing at 48 months compared with control (saline) (very low certainty).

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  48 months
  RR 5.60 [2.22, 14.11]
  1 study · 73 participants
  Very low

Benzethonium chloride mouthwash vs Placebo mouthwash

Benzethonium chloride mouthwash showed no clear difference in VSC: dimethyl sulphide compared with placebo mouthwash; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  9 days
  MD -0.03 [-0.63, 0.57]
  1 study · 20 participants
  GRADE not reported

Toothbrushing + 0.075% cetylpyridinium chloride mouthwash vs Toothbrushing alone

The review found no eligible studies for this question.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 3 weeks
  Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
  0 studies
  No studies found

Cetylpyridinium chloride mouthwash vs Chlorhexidine + zinc mouthwash

It is very uncertain whether cetylpyridinium chloride mouthwash changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with chlorhexidine + zinc mouthwash (very low certainty).

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 2 weeks
  MD -0.33 [-0.72, 0.06]
  1 study · 44 participants
  Very low

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

Mechanical tongue cleaning (tongue scraper) showed no clear difference in volatile sulphur compounds (VSC) compared with no tongue cleaning; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  1 week
  MD -7.69 [-47.08, 31.69]
  2 studies · 46 participants
  GRADE not reported

Oral hygiene care training of carers vs No training (or a placebo training session) of carers

Oral hygiene care training of carers showed no clear difference in gingival inflammation (medium term) compared with no training (or a placebo training session) of carers (low certainty).

• Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes

  Medium term (6 weeks to 12 months)
  MD -0.09 [-0.63, 0.45]
  2 studies · 99 participants
  Low

Toothbrushing + Turkish gall oral rinse vs Toothbrushing alone

Toothbrushing + Turkish gall oral rinse showed no clear difference in dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with toothbrushing; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  2 weeks
  MD -0.1 [-0.5, 0.3]
  1 study · 66 participants
  GRADE not reported

Ledermix root canal medicament (day 0 to 10) vs Ultracal root canal medicament (day 7 to 10)

It is very uncertain whether ledermix root canal medicament (day 0 to 10) changes periodontal healing at 12 months (tooth level) compared with ultracal root canal medicament (day 7 to 10) (very low certainty).

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  12 months
  RR 1.67 [0.80, 3.49]
  1 study · 22 participants
  Very low

Essential oil mouthwash vs Placebo mouthwash

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  2 weeks
  Adverse events reported by Borden 2002 were not related to the interventions.
  1 study · 45 participants
  GRADE not reported

Lactobacillus beta lactoperoxidase (LPO) tablets vs placebo (3 tablets/4 times a day

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Nakano 2017 (2-arm trial) compared Lactobacillus beta LPO tablets versus placebo tablets (VSC by OralChroma). The trial did not report any usable data and hence could not be included in the analysis.
  1 study
  GRADE not reported

Triphala and Ela decoction mouthwash vs Chlorhexidine mouthwash

It is very uncertain whether triphala and Ela decoction mouthwash changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with chlorhexidine mouthwash (very low certainty).

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 2 weeks
  MD 0.2 [0.09, 0.31]
  1 study · 60 participants
  Very low

Triclosan/copolymer-containing fluoride toothpaste vs Sodium fluoride (control) toothpaste

The review found no eligible studies for this question.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 1 week
  Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
  0 studies
  No studies found

Daily toothbrushing by a dental student vs Twice-weekly or once-weekly toothbrushing by a dental student

• Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes

  Short term (<6 weeks)
  Daily vs twice-weekly or once-weekly toothbrushing by dental students. Buccal and labial Loe & Silness index, mean 21 days; 80 participants (1 RCT); Low. Brushing daily most likely reduced gingival inflammation more…
  1 study · 80 participants
  Low

Hinokitiol gel vs Placebo gel

Hinokitiol gel showed no clear difference in VSC: hydrogen sulphide compared with placebo gel; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  28 days
  MD -2.13 [-5.33, 1.08]
  1 study · 18 participants
  GRADE not reported

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

It is very uncertain whether combined HBO and perioperative antibiotics prior to dental implant… changes incidence of ORN compared with antibiotics alone prior to dental implant therapy (very low certainty).

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  1 year
  RR 3.00 [0.14, 65.16]
  1 study · 26 participants
  Very low

Special manual toothbrush (self, carer or carer-assisted brushing) vs Manual toothbrush

It is very uncertain whether special manual toothbrush (self, carer or carer-assisted brushing) changes gingival inflammation (medium term) compared with conventional manual toothbrush (self, carer or carer-assisted… (very low certainty).

• Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes

  Medium term (6 weeks to 12 months)
  MD -12.40 [-24.31, -0.49]
  1 study · 18 participants
  Very low

Cetylpyridinium chloride mouthwash vs Chlorhexidine + zinc mouthwash

Cetylpyridinium chloride mouthwash showed no clear difference in volatile sulphur compounds (VSC) compared with chlorhexidine + zinc mouthwash; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  2 weeks
  MD 0.49 [-8.68, 9.66]
  1 study · 44 participants
  GRADE not reported

Discussion of individual clinical photographs (plaque highlighted by a disclosing agent) as an oral hygiene motivator, plus oral hygiene instruction vs No discussion of clinical photographs, but received the same oral hygiene instruction

It is very uncertain whether discussion of individual clinical photographs (plaque highlighted by… changes plaque (medium term) compared with no discussion of clinical photographs, but received the same oral… (very low certainty).

• Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes

  Medium term (6 weeks to 12 months)
  MD -0.10 [-0.85, 0.65]
  1 study · 29 participants
  Very low

Halita mouthrinse vs Perio-plus mouthrinse

It is very uncertain whether halita mouthrinse changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with perio-plus mouthrinse (very low certainty).

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 8 days
  MD -0.2 [-0.86, 0.46]
  1 study · 36 participants
  Very low

1000 mg champignon extract vs 50 mg champignon extract

1000 mg champignon extract showed no clear difference in patient's family member-reported VAS score (scale 0 to 100) compared with 50 mg champignon extract; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  2 weeks
  MD -0.61 [-15.58, 14.36]
  1 study · 40 participants
  GRADE not reported