Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Corticosteroids vs placebo

Endoscopic improvement (dichotomous) · active EoE patients

Corticosteroids showed no clear difference in endoscopic improvement (dichotomous) compared with placebo (low certainty).

1 finding from 1 review

Corticosteroids vs placebo

Withdrawals due to adverse events · active EoE patients

Corticosteroids may leads to lower withdrawals due to adverse events (2 to 12 weeks) compared with placebo (low certainty).

1 finding from 1 review

Corticosteroids vs placebo

Clinical improvement (dichotomous) · inactive EoE patients

It is very uncertain whether corticosteroids changes clinical improvement (dichotomous) compared with placebo (very low certainty).

1 finding from 1 review

Viaskin milk patch vs placebo

Withdrawals due to adverse events · active EoE pediatric patients

Viaskin milk patch showed no clear difference in withdrawals due to adverse events at 44 weeks compared with placebo (low certainty).

1 finding from 1 review

Inhaled tobramycin (TNS) vs placebo

Eradication of P aeruginosa from the respiratory tract: proportion with positive respiratory culture for P aeruginosa · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Inhaled tobramycin (TNS) may leads to lower eradication of P aeruginosa from the respiratory tract: proportion… compared with placebo (low certainty).

1 finding from 1 review

Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy

Eradication of P aeruginosa from the respiratory tract: proportion of participants with one or more isolates of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy

Pulmonary exacerbations · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Ciprofloxacin showed no clear difference in frequency of infective pulmonary exacerbations: proportion of… compared with placebo added to cycled and culture‐based inhaled tobramycin (TNS)… (moderate certainty).

1 finding from 1 review