Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less
Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
RR 1.20 [0.85, 1.70]
10 studies
GRADE not reported
Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less
Fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride mouthrinse; GRADE not reported.
1 finding from 1 review
RR 0.89 [0.78, 1.00]
5 studies
GRADE not reported
Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less
Fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs) compared with any other topical fluoride (gel or mouthrinse); GRADE not reported.
1 finding from 1 review
RR 0.88 [0.78, 1.00]
6 studies
GRADE not reported
Aesthetics · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes aesthetics compared with fluoride varnish (very low certainty).
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes dental pain or sensitivity compared with fluoride varnish (very low certainty).
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Gao 2019 noted that "arrested lesions were stained black" (reported with no associated data). No other adverse effects observed, and no reports from parents of systemic disease.
1 study · 1070 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, black or brown staining on treated lesions was more common after SDF (OR 3.19, 95% CI 1.95 to 5.23), with no other adverse effects. 1 study reported complaints of a transient bitter taste with SDF use (with…
3 studies · 980 participants
Very low
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Fluorosis (adverse effect; % of children with fluorotic teeth) · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Plaque and gingivitis scores · Children and adolescents aged 16 years or less
1 finding from 1 review
Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less
Fluoride gel combined with fluoride mouthrinse showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride gel alone; GRADE not reported.
1 finding from 1 review
Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less
Fluoride mouthrinse combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride mouthrinse alone; GRADE not reported.
1 finding from 1 review
Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less
Fluoride mouthrinse combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.
1 finding from 1 review
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
SoF2: No evidence of a difference between interventions in caries after 1, 2 and 3 years; 995 (3 studies); Very low. Studies were clinically different so not combined in meta-analyses; 1 study (Tagliaferro 2011)…
3 studies · 995 participants
Very low
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
It is very uncertain whether resin-based fissure sealant changes dentine caries in permanent molars (yes/no) compared with fluoride varnish (very low certainty).
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review