Findings

What do systematic reviews say?

64 questions · 65 findings · 2 reviews · Skin

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No studies found 30 · 46.2%GRADE not reported 0 · 0%Very low 20 · 30.8%Low 13 · 20%Moderate 2 · 3.1%High 0 · 0%

Azelaic acid vs benzoyl peroxide

Treatment withdrawal · participants with acne

Azelaic acid showed no clear difference in withdrawal for any reason (long term: treatment duration > 8 weeks) compared with benzoyl peroxide (low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 0.88 [0.6, 1.29]
1 study · 351 participants
Low

Azelaic acid vs benzoyl peroxide

Minor adverse events · participants with acne

It is very uncertain whether azelaic acid changes total number of participants who experienced at least one minor… compared with benzoyl peroxide (very low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 0.5 [0.05, 4.94]
1 study · 30 participants
Very low

Azelaic acid vs benzoyl peroxide

Quality of life · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Azelaic acid vs clindamycin

Participants' global self‐assessment of acne improvement Good or very good improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good or… compared with clindamycin (low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 1.13 [0.92, 1.38]
1 study · 229 participants
Low