Findings

What do systematic reviews say?

67 questions · 67 findings · 3 reviews · Injuries

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No studies found 5 · 7.5%GRADE not reported 2 · 3%Very low 16 · 23.9%Low 36 · 53.7%Moderate 8 · 11.9%High 0 · 0%

Intervention not reported

TXA given intravenously and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…

1 finding from 1 review

Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a… 2024 · Cochrane Headline outcomes only
no estimate extracted
3 participants
Low

DDAVP vs tranexamic acid (control)

Red cell volume transfused (total) · participants undergoing surgery

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

DDAVP vs tranexamic acid (control)

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

It is very uncertain whether DDAVP changes number of participants receiving a red cell transfusion (total) compared with tranexamic acid (very low certainty).

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
RR 2.42 [1.04, 5.64]
3 studies · 135 participants
Very low

DDAVP vs tranexamic acid (control)

Blood loss (total) · participants undergoing surgery

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 115 participants
Low

DDAVP vs tranexamic acid (control)

All‐cause mortality · participants undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

DDAVP vs tranexamic acid (control)

All thrombotic events (including myocardial infarction, ischaemic stroke, other arterial thromboembolism, and venous thromboembolism) · participants undergoing surgery

It is very uncertain whether DDAVP changes all thrombotic events (including myocardial infarction, ischaemic… compared with tranexamic acid (very low certainty).

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
RR 2.92 [0.32, 26.83]
2 studies · 115 participants
Very low

DDAVP vs tranexamic acid (control)

Quality of life · participants undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found