Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

101 questions · 108 findings · 12 reviews · Skin

No studies found 7 · 6.5%GRADE not reported 9 · 8.3%Very low 19 · 17.6%Low 38 · 35.2%Moderate 30 · 27.8%High 5 · 4.6%

Potent vs moderate‐potency topical corticosteroid

Patient‐reported symptoms of eczema · children and adults, most with moderate to severe eczema

Potent may leads to lower patient‐reported symptoms of eczema: PGA; short‐term (week 1) compared with moderate‐potency topical corticosteroid (low certainty).

1 finding from 1 review

Very potent vs potent topical corticosteroid

Clinician‐reported signs of eczema: IGA (number with cleared or marked improvement); short term (earliest time point within 1‐2 weeks) · adults with eczema

Very potent showed no clear difference in clinician‐reported signs of eczema: IGA (number with cleared or… compared with potent topical corticosteroid (low certainty).

1 finding from 1 review

Very potent vs potent topical corticosteroid

Local adverse events: skin thinning; end of treatment (1 to 3 weeks) · adults with eczema

It is very uncertain whether very potent changes local adverse events: skin thinning; end of treatment (day 11‐day 22) compared with potent topical corticosteroid (very low certainty).

1 finding from 1 review

Twice daily or more vs once daily topical corticosteroid

Clinician‐reported signs of eczema: IGA (number with cleared or marked improvement); short term (earliest time point within 1‐4 weeks) · children and adults, most with moderate to severe eczema

Twice daily or more showed no clear difference in clinician‐reported signs of eczema: IGA (number with cleared or… compared with once daily topical corticosteroid (moderate certainty).

1 finding from 1 review

Twice daily or more vs once daily topical corticosteroid

Patient‐reported symptoms of eczema · children and adults, most with moderate to severe eczema

Twice daily or more showed no clear difference in patient‐reported symptoms of eczema: PGA (number with cleared or… compared with once daily topical corticosteroid (low certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Clinician‐reported signs of eczema: number of participants with one or more relapses (16‐20 weeks) · children and adults with mild to severe eczema

Weekend therapy probably leads to lower clinician‐reported signs of eczema: number of participants with one… compared with no topical corticosteroid (moderate certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Local adverse events: skin thinning; end of treatment (16‐20 weeks + 2‐4 weeks acute phase) · children and adults with mild to severe eczema

Weekend therapy may leads to lower local adverse events: skin thinning; end of treatment (16‐20 weeks +… compared with no topical corticosteroid (low certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Systemic adverse events: abnormal cortisol; end of treatment (16 weeks + 4 weeks acute phase) · children and adults with mild to severe eczema

It is very uncertain whether weekend therapy changes systemic adverse events: abnormal cortisol; end of treatment (16… compared with no topical corticosteroid (very low certainty).

1 finding from 1 review