Findings

What do systematic reviews say?

216 questions · 222 findings · 3 reviews · Endodontics and dental trauma

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No studies found 8 · 3.6%GRADE not reported 150 · 67.6%Very low 29 · 13.1%Low 26 · 11.7%Moderate 9 · 4.1%High 0 · 0%

Portland cement (PC) vs EMD (enamel matrix derivative) alone

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Portland cement (PC) showed no clear difference in radiological failure compared with enamel matrix derivative (EMD); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.57 [0.18, 1.78]
1 study · 70 participants
GRADE not reported

Diode laser vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Diode laser showed no clear difference in clinical failure compared with ferric sulphate (FS) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.23 [0.04, 1.30]
3 studies · 130 participants
Low

Biodentine vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
No radiological failure in any participant; not estimable
1 study · 62 participants
GRADE not reported

Calcium hydroxide (CH) vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide (CH) showed no clear difference in clinical failure compared with ferric sulphate (FS) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 3.41 [0.37, 31.61]
2 studies · 122 participants
Low

Mineral trioxide aggregate (MTA) vs Full strength or 1:5 diluted formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) probably leads to lower radiological failure compared with full strength or 1:5 diluted formocresol (FC) (moderate certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.41 [0.19, 0.89]
12 studies · 740 participants
Moderate

Self-etch adhesive + acetone-based total-etch adhesive vs Non-rinse conditioner + acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes radiological failure compared with non-rinse conditioner + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 1.00 [0.07, 14.90]
1 study · 40 participants
Very low

Mineral trioxide aggregate (MTA) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) may leads to lower clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.17 [0.04, 0.70]
1 study · 160 participants
Low

Self-etch adhesive + acetone-based total-etch adhesive vs Total-etching 36% phosphoric acid + acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with total-etching 36% phosphoric acid + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 1.00 [0.07, 14.90]
1 study · 40 participants
Very low

Mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl) vs Calcium hydroxide + sodium hypochlorite (NaOCl)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
No clinical failure in any participant (Akcay 2014); not estimable
1 study · 62 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Portland cement (PC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) showed no clear difference in radiological failure compared with portland cement (PC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.50 [0.10, 2.56]
3 studies · 130 participants
GRADE not reported

Low‐level laser therapy vs Low-level laser therapy (LLLT) + calcium hydroxide

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
No clinical failure in any participant (Fernandes 2015); not estimable
1 study · 30 participants
GRADE not reported

ProRoot MTA vs RetroMTA

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
No clinical failure in any participant (Kang 2015); not estimable
1 study · 96 participants
GRADE not reported

Bee propolis (one 500 mg capsule per day) vs Mineral trioxide aggregate (MTA)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Propolis showed no clear difference in radiological failure compared with mineral trioxide aggregate (MTA); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 3.50 [0.80, 15.23]
1 study · 50 participants
GRADE not reported

Biodentine vs Formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
No radiological failure in any participant; not estimable
1 study · 112 participants
GRADE not reported

Non-rinse conditioner + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether non-rinse conditioner + acetone-based total-etch adhesive changes radiological failure compared with calcium hydroxide (CH) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 3.00 [0.13, 69.52]
1 study · 40 participants
Very low

Calcium hydroxide (CH) vs Portland cement (PC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide (CH) showed no clear difference in clinical failure compared with portland cement (PC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 13.00 [0.80, 212.02]
1 study · 30 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Full strength or 1:5 diluted formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) probably leads to lower clinical failure compared with full strength or 1:5 diluted formocresol (FC) (moderate certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.31 [0.10, 0.93]
12 studies · 740 participants
Moderate

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes radiological failure compared with calcium hydroxide (CH) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 7.00 [0.38, 127.33]
1 study · 40 participants
Very low

Calcium hydroxide (CH) vs Mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide (CH) showed no clear difference in clinical failure compared with mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 3.00 [0.13, 70.92]
1 study · 62 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Portland cement (PC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) showed no clear difference in clinical failure compared with portland cement (PC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6, 12 and 24 months
RR 0.20 [0.01, 4.02]
3 studies · 130 participants
GRADE not reported