Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

184 questions · 199 findings · 25 reviews

No studies found 45 · 22.6%GRADE not reported 10 · 5%Very low 48 · 24.1%Low 35 · 17.6%Moderate 42 · 21.1%High 19 · 9.5%

Stopping LABA vs continuing use of LABA+ICS

Rate of exacerbations requiring systemic corticosteroids · adults with asthma well controlled on LABA and ICS

Stopping LABA showed no clear difference in exacerbation: systemic corticosteroids 17 weeks compared with continuing use of LABA+ICS (moderate certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Mortality Mortality at latest · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids showed no clear difference in mortality at latest reported age compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

BPD (36 weeks' PMA) · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids probably leads to lower BPD (36 weeks' PMA) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Death or bronchopulmonary dysplasia at 36 weeks PMA · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids leads to lower mortality or BPD at 36 weeks' PMA compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Gastrointestinal perforation during primary hospitalisation · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids leads to higher gastrointestinal perforation during primary hospitalisation compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Cerebral palsy · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids leads to higher cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).

1 finding from 1 review

Early systemic postnatal corticosteroids vs placebo or no treatment

Death or cerebral palsy · preventing bronchopulmonary dysplasia in preterm infants

Early systemic postnatal corticosteroids showed no clear difference in mortality or cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).

1 finding from 1 review

Vitamin D vs placebo

Rate of exacerbations requiring systemic corticosteroids · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more exacerbations treated… compared with placebo (high certainty).

1 finding from 1 review

Mepolizumab subcutaneous (SC) vs placebo

Rate of clinically significant exacerbations requiring systemic corticosteroids · people with asthma

Mepolizumab subcutaneous (SC) leads to lower rate of clinically significant exacerbations requiring systemic… compared with placebo (high certainty).

1 finding from 1 review

Reslizumab intravenous (IV) vs placebo

Rate of clinically significant exacerbations requiring systemic corticosteroids · people with asthma

Reslizumab intravenous (IV) leads to lower rate of clinically significant exacerbations requiring systemic… compared with placebo (high certainty).

1 finding from 1 review

Reslizumab subcutaneous (SC) vs placebo

Rate of clinically significant exacerbations requiring systemic corticosteroids · people with asthma

Reslizumab subcutaneous (SC) showed no clear difference in rate of clinically significant exacerbations requiring systemic… compared with placebo (high certainty).

1 finding from 1 review

Benralizumab subcutaneous (SC) vs placebo

Rate of clinically significant exacerbations requiring systemic corticosteroids · people with asthma

Benralizumab subcutaneous (SC) leads to lower rate of clinically significant exacerbations requiring systemic… compared with placebo (high certainty).

1 finding from 1 review

Mepolizumab intravenous (IV) vs placebo

Rate of clinically significant exacerbations requiring systemic corticosteroids · people with asthma

Mepolizumab intravenous (IV) leads to lower rate of clinically significant exacerbations requiring systemic… compared with placebo (high certainty).

1 finding from 1 review

Corticosteroids vs no corticosteroid use

Disease‐specific mortality ‐ SJS and TEN (time to · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

It is very uncertain whether corticosteroids changes disease‐specific mortality ‐ SJS and TEN (time to compared with no corticosteroids (very low certainty).

1 finding from 1 review