Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

193 questions · 205 findings · 27 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 46 · 22.4%GRADE not reported 4 · 2%Very low 54 · 26.3%Low 50 · 24.4%Moderate 35 · 17.1%High 16 · 7.8%

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

Local tumor control · Patients with brain metastases

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) probably leads to lower local tumor control compared with WBRT (moderate certainty).

1 finding from 1 review

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

Functionally independent survival (KPS) · Patients with brain metastases

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) showed no clear difference in functionally independent survival (KPS) compared with WBRT (moderate certainty).

1 finding from 1 review

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

Overall survivalNo. of participants: 2631(8 RCTs) · patients with newly diagnosed multiple brain metastases

WBRT and radiosurgery showed no clear difference in overall survivalNo. of participants: 358(2 RCTs) compared with WBRT (moderate certainty).

1 finding from 1 review

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

1‐Year overall brain control ratesNo. of participants: 400(3 RCTs) · patients with newly diagnosed multiple brain metastases

WBRT and radiosurgery leads to lower 1‐Year overall brain control ratesNo. of participants: 400(3 RCTs) compared with WBRT (high certainty).

1 finding from 1 review

Enhanced recovery protocol vs traditional care

Overall postoperative complications (within 30 days of operation) · women with gynaecological cancers

Enhanced recovery after surgery programme showed no clear difference in overall postoperative complications (within 30 days of operation) compared with traditional care (low certainty).

1 finding from 1 review

Suprapubic catheterisation vs intermittent self‐catheterisation

Adverse events (acute complication after surgery)

It is very uncertain whether suprapubic catheterisation changes adverse events (acute complication after surgery) compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Suprapubic catheterisation vs intermittent self‐catheterisation

Urinary tract infection

It is very uncertain whether suprapubic catheterisation changes urinary tract infections in the first month after surgery compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review