Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

138 questions · 142 findings · 24 reviews

No studies found 28 · 19.7%GRADE not reported 7 · 4.9%Very low 31 · 21.8%Low 44 · 31%Moderate 30 · 21.1%High 2 · 1.4%

Hyaluronic acid‐selected sperm (HA‐ICSI) vs viscous medium containing HA (SpermSlow)

Live birth rate per woman · assisted reproduction

It is very uncertain whether hyaluronic acid‐selected sperm (HA‐ICSI) changes live birth per woman randomly assigned compared with viscous medium containing HA (SpermSlow) (very low certainty).

1 finding from 1 review

Hyaluronic acid‐selected sperm (HA‐ICSI) vs viscous medium containing HA (SpermSlow)

Miscarriage per clinical pregnancy · assisted reproduction

It is very uncertain whether hyaluronic acid‐selected sperm (HA‐ICSI) changes miscarriage per clinical pregnancy compared with viscous medium containing HA (SpermSlow) (very low certainty).

1 finding from 1 review

Hyaluronic acid‐selected sperm (HA‐ICSI) vs viscous medium containing HA (SpermSlow)

Clinical pregnancy · assisted reproduction

It is very uncertain whether hyaluronic acid‐selected sperm (HA‐ICSI) changes clinical pregnancy per woman randomly assigned compared with viscous medium containing HA (SpermSlow) (very low certainty).

1 finding from 1 review

Rapid vs slow taper of buprenorphine dose

Completion of withdrawal treatment − Outpatient · Adults or adolescents with opioid dependence

It is very uncertain whether rapid changes completion of withdrawal treatment − Outpatient compared with slow taper of buprenorphine dose (very low certainty).

1 finding from 1 review

Rapid vs slow taper of buprenorphine dose

Number abstinent at completion of dose taper − Outpatient · Adults or adolescents with opioid dependence

It is very uncertain whether rapid changes number abstinent at completion of dose taper − Outpatient compared with slow taper of buprenorphine dose (very low certainty).

1 finding from 1 review

Rapid vs slow taper of buprenorphine dose

Completion of withdrawal treatment − Inpatient · Adults or adolescents with opioid dependence

Rapid showed no clear difference in completion of withdrawal treatment − Inpatient compared with slow taper of buprenorphine dose (low certainty).

1 finding from 1 review

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD

Antioxidant multivitamin and mineral supplement probably leads to lower progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Lutein with or without zeaxanthin vs placebo

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to visual loss (loss of 3 or more lines on logMAR chart) compared with placebo (low certainty).

1 finding from 1 review