Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

303 questions · 322 findings · 45 reviews

No studies found 31 · 9.6%GRADE not reported 22 · 6.8%Very low 99 · 30.7%Low 95 · 29.5%Moderate 68 · 21.1%High 7 · 2.2%

Selective serotonin reuptake inhibitors vs atypical agent

Improvement in depression at 6‐12 weeks: HAM‐D score (dichotomized) · adults living with HIV and depression

Selective serotonin reuptake inhibitor (SSRI) showed no clear difference in improvement in depression at 6‐12 weeks: HAM‐D score (dichotomized) compared with atypical agent (low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors vs atypical agent

Improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) · adults living with HIV and depression

Selective serotonin reuptake inhibitor (SSRI) showed no clear difference in improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) compared with atypical agent (low certainty).

1 finding from 1 review