Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

188 questions · 190 findings · 13 reviews · Headline outcomes only

No studies found 50 · 26.3%GRADE not reported 0 · 0%Very low 48 · 25.3%Low 52 · 27.4%Moderate 30 · 15.8%High 10 · 5.3%

Azelaic acid vs clindamycin

Participants' global self‐assessment of acne improvement Good or very good improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good or… compared with clindamycin (low certainty).

1 finding from 1 review

IVIg vs acetylsalicylic acid (ASA)

Incidence of any adverse effects after treatment initiation ( · people undergoing initial treatment for KD

It is very uncertain whether primary treatment with intravenous immunoglobulin (IVIG) changes incidence of any adverse effects after treatment initiation (from 30… compared with acetylsalicylic acid (ASA) (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs salicylic acid

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review