Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

107 questions · 110 findings · 14 reviews · Neuromuscular

No studies found 17 · 15.5%GRADE not reported 21 · 19.1%Very low 47 · 42.7%Low 20 · 18.2%Moderate 5 · 4.5%High 0 · 0%

Hydroxytryptophan vs placebo

Short‐term (within 1 month) change in isolated movement, objective and subjective measures of speech production Wessel 1995: Mean syllable duration during rapid‐syllable repetition task. Scale from: 1 to 500. Shorter durations are better. · people with speech disorder resulting from hereditary ataxias
1 finding from 1 review

Riluzole vs placebo

Short‐term (within 1 month) change in isolated movement, objective and subjective measures of speech production Cooper 2008 reported 3 speech measures: ICARS speech subscale. Scale from: 0 to 8. Higher scores indicate greater clinical severity Syl... · people with speech disorder resulting from hereditary ataxias
1 finding from 1 review

Idebenone vs placebo

Short‐term (within 1 month) change in isolated movement, objective and subjective measures of speech production Cooper 2008 reported 3 speech measures: ICARS speech subscale. Scale from: 0 to 8. Higher scores indicate greater clinical severity Syl... · people with speech disorder resulting from hereditary ataxias
1 finding from 1 review

Physiotherapy and occupational therapy vs placebo

Short‐term (1 week) change in isolated movement, objective and subjective measures of speech production SARA. Scale from: 0 to 6. Higher scores indicate more severe speech disorder. · people with speech disorder resulting from hereditary ataxias
1 finding from 1 review

Physiotherapy and occupational therapy vs placebo

Short‐term (1 week) change in quality of life scores related to communication as measured by validated communication assessments Functional Independence Measure (total). Scale from: 0 to 126. Higher scores indicate less disability · people with speech disorder resulting from hereditary ataxias
1 finding from 1 review

Betamethasone vs placebo

Short‐term (within 1 month) change in isolated movement, objective and subjective measures of speech production Cooper 2008 reported 3 speech measures: ICARS speech subscale. Scale from: 0 to 8. Higher scores indicate greater clinical severity Syl... · people with speech disorder resulting from hereditary ataxias
1 finding from 1 review