Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

162 questions · 167 findings · 24 reviews · Musculoskeletal

No studies found 65 · 38.9%GRADE not reported 6 · 3.6%Very low 24 · 14.4%Low 55 · 32.9%Moderate 16 · 9.6%High 1 · 0.6%

Febuxostat 120 mg/day vs allopurinol

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 120 mg/day probably leads to higher serum uric acid <6.0 mg/dL at final visit compared with allopurinol (moderate certainty).

1 finding from 1 review

Febuxostat 80 mg/day vs placebo

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 80 mg/day may leads to higher serum uric acid <6.0 mg/dL at final visit compared with placebo (low certainty).

1 finding from 1 review