Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

212 questions · 217 findings · 28 reviews · Headline outcomes only

No studies found 53 · 24.4%GRADE not reported 6 · 2.8%Very low 24 · 11.1%Low 69 · 31.8%Moderate 47 · 21.7%High 18 · 8.3%

Casirivimab/imdevimab vs placebo

Development of clinical COVID‐19 symptoms within 30 days · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab leads to lower development of clinical COVID‐19 symptoms within 30 days compared with placebo (high certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review