Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

290 questions · 295 findings · 24 reviews · Haematology

No studies found 73 · 24.7%GRADE not reported 23 · 7.8%Very low 55 · 18.6%Low 96 · 32.5%Moderate 37 · 12.5%High 11 · 3.7%

Casirivimab/imdevimab vs placebo

Development of clinical COVID‐19 symptoms within 30 days · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab leads to lower development of clinical COVID‐19 symptoms within 30 days compared with placebo (high certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review