Findings

What do systematic reviews say?

167 questions · 167 findings · 5 reviews · Common Mental Disorders

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No studies found 1 · 0.6%GRADE not reported 40 · 24%Very low 13 · 7.8%Low 14 · 8.4%Moderate 96 · 57.5%High 3 · 1.8%

Paroxetine vs bupropion

SMD at endpoint · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 132 participants
Moderate

Paroxetine vs bupropion

Failure to complete ‐ any cause ‐ · patients with depression

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with bupropion (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.16 [0.62, 2.2]
2 studies · 240 participants
Moderate

Paroxetine vs bupropion

Participants with at least some Side Effects · patients with depression

Paroxetine showed no clear difference in participants with at least some Side Effects compared with bupropion (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.6 [0.43, 5.92]
1 study · 140 participants
Moderate

Paroxetine vs citalopram

Failure to respond at endpoint (6‐12 weeks) · patients with depression

Paroxetine probably leads to higher failure to respond at endpoint (6‐12 weeks) compared with citalopram (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.54 [1.04, 2.28]
1 study · 406 participants
Moderate

Paroxetine vs citalopram

Failure to respond at 1‐4 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs citalopram

Failure to respond at 16‐24 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs citalopram

Failure to remit at endpoint · patients with depression

The review found no eligible studies for this question.

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paroxetine vs older ADs

Failure to remit at endpoint · patients with depression

Paroxetine showed no clear difference in failure to remit at endpoint compared with older ADs (low certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.23 [0.49, 3.07]
3 studies · 401 participants
Low

Paroxetine vs citalopram

SMD at endpoint · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 201 participants
Moderate

Paroxetine vs citalopram

Failure to complete ‐ any cause ‐ · patients with depression

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with citalopram (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.99 [0.61, 1.6]
1 study · 406 participants
Moderate

Paroxetine vs citalopram

Participants with at least some Side Effects · patients with depression

Paroxetine showed no clear difference in participants with at least some Side Effects compared with citalopram (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.74 [0.46, 1.21]
1 study · 406 participants
Moderate

Paroxetine vs duloxetine

Failure to respond at endpoint (6‐12 weeks) · patients with depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with duloxetine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.89 [0.7, 1.14]
6 studies · 1821 participants
Moderate

Paroxetine vs duloxetine

Failure to respond at 1‐4 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs duloxetine

Failure to respond at 16‐24 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs duloxetine

Failure to remit at endpoint · patients with depression

Paroxetine showed no clear difference in failure to remit at endpoint compared with duloxetine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.98 [0.8, 1.19]
6 studies · 1821 participants
Moderate

Paroxetine vs duloxetine

SMD at endpoint · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1481 participants
Moderate

Paroxetine vs duloxetine

Failure to complete ‐ any cause ‐ · patients with depression

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with duloxetine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.97 [0.77, 1.23]
6 studies · 1821 participants
Moderate

Paroxetine vs duloxetine

Participants with at least some Side Effects · patients with depression

Paroxetine showed no clear difference in participants with at least some Side Effects compared with duloxetine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.81 [0.64, 1.01]
6 studies · 1870 participants
Moderate

Paroxetine vs older ADs

SMD at endpoint · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
35 studies · 4745 participants
Moderate

Paroxetine vs escitalopram

Failure to respond at endpoint (6‐12 weeks) · depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with escitalopram (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.12 [0.76, 1.65]
2 studies · 784 participants
Moderate