What do systematic reviews say?

Intraoral device releasing Biotene Oral Balance gel vs Manually administered bolus of the same gel

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  No difference between device and bolus in unstimulated whole saliva, oral microbial profile or generalised inflammation.
  1 study · 22 participants
  GRADE not reported

Mucin spray (Saliva Orthana) vs Placebo spray (base without mucin)

Mucin spray (Saliva Orthana) led to lower improvement in dry mouth (dichotomous) compared with placebo spray (base without mucin); GRADE not reported.

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Sweeney 1997 (parallel, n=31, terminal cancer): both sprays improved dry mouth symptoms but no statistically significant difference between mucin spray and placebo for improved dry mouth (Analysis 1.1; RR not…
  1 study · 31 participants
  GRADE not reported

Commercial mouthcare system (Biotene Oral Balance / Xerostom) vs Bioxtra mouthcare system

Biotene Oral Balance mouthcare system led to higher xerostomia (VAS mouth dryness) compared with bioxtra mouthcare system; GRADE not reported.

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  SMD 0.69 [0.08, 1.30]
  1 study · 20 participants
  GRADE not reported

OASIS moisturising mouthwash vs Experimental mouthwash formulation

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Shirodaria 2006 (crossover): OASIS reported to give a statistically significant improvement over subjects' normal remedies, but the report did not present the randomised OASIS-versus-experimental comparison; no data…
  1 study
  GRADE not reported

V6 chewing gum / mucin chewing gum vs Placebo chewing gum

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Aagaard 1992 (crossover, n=43): approximately 50% of participants had an increase in unstimulated whole saliva from all products; unclear how many completed the trial; no usable data.
  1 study · 43 participants
  GRADE not reported

V6 chewing gum / mucin chewing gum vs Placebo chewing gum

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Preference favoured mucin gum (61%) over V6 (21%) and placebo (5%).
  1 study · 43 participants
  GRADE not reported

CMC/sorbitol pre-moistened swabs vs Lemon glycerin swabs

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Patient preference favoured CMC/sorbitol (Chi2 10.89, df=1; P = 0.001).
  1 study · 20 participants
  GRADE not reported