Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

216 questions · 218 findings · 21 reviews · Heart

No studies found 30 · 13.8%GRADE not reported 1 · 0.5%Very low 49 · 22.5%Low 71 · 32.6%Moderate 48 · 22%High 19 · 8.7%

Higher polyunsaturated fatty acid (PUFA) vs lower PUFA

Major adverse cardiac and cerebrovascular events · people with or without existing CVD, men and women

It is very uncertain whether higher polyunsaturated fatty acid (PUFA) changes major adverse cardiac and cerebrovascular events compared with lower PUFA (very low certainty).

1 finding from 1 review

Higher polyunsaturated fatty acid (PUFA) vs lower PUFA

Cardiovascular events · people with or without existing cardiovascular disease, men and women

Higher polyunsaturated fatty acid (PUFA) showed no clear difference in cardiovascular events compared with lower PUFA (moderate certainty).

1 finding from 1 review

Higher polyunsaturated fatty acid (PUFA) vs lower PUFA

Coronary heart disease mortality – CHD deaths · people with or without existing cardiovascular disease, men and women

Higher polyunsaturated fatty acid (PUFA) showed no clear difference in coronary heart disease mortality compared with lower PUFA (low certainty).

1 finding from 1 review

Higher polyunsaturated fatty acid (PUFA) vs lower PUFA

Atrial fibrillation and arrhythmias · people with or without existing cardiovascular disease, men and women

It is very uncertain whether higher polyunsaturated fatty acid (PUFA) changes atrial fibrillation and arrhythmias compared with lower PUFA (very low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in myocardial infarction compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Stroke · people with or without existing cardiovascular disease, men and women

It is very uncertain whether homocysteine‐lowering interventions (high dose) changes stroke compared with homocysteine‐lowering interventions (low dose) (very low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Advance care planning vs usual care

Quality of communication Measured on Quality of Patient‐Clinician Communication About End‐of‐Life Care. Higher score indicates high satisfaction with the quality of communication Assessed after intervention · people with heart failure with or without their surrogate decision‐makers/carers
1 finding from 1 review