Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

227 questions · 258 findings · 32 reviews

No studies found 68 · 26.4%GRADE not reported 32 · 12.4%Very low 47 · 18.2%Low 70 · 27.1%Moderate 34 · 13.2%High 7 · 2.7%

High‐dose colchicine vs placebo

Proportion with 50% or greater decrease in inflammation score from baseline ‐ 32 to 36 hours · acute gout

High‐dose colchicine may leads to higher reduction of inflammation: proportion with 50% or greater decrease… compared with placebo (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Total adverse events · acute gout

High‐dose colchicine may leads to higher total adverse events compared with placebo (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

High‐dose colchicine may leads to higher participant global assessment of treatment success: proportion with… compared with placebo (low certainty).

1 finding from 1 review