Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

80 questions · 80 findings · 5 reviews

No studies found 16 · 20%GRADE not reported 7 · 8.8%Very low 32 · 40%Low 15 · 18.8%Moderate 6 · 7.5%High 4 · 5%

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Death from any cause · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes death from any cause compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

TB‐related death · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes TB‐related death compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Sputum culture conversion at 8 weeks · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes sputum culture conversion at 8 weeks compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes serious adverse events compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Death from any cause · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in death from any cause compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

TB‐related death · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in TB‐related death compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Sputum culture conversion at 8 weeks · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in sputum culture conversion at 8 weeks compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in serious adverse events compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Relapse · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes relapse compared with standard regimen (very low certainty).

1 finding from 1 review