Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

107 questions · 135 findings · 11 reviews

No studies found 31 · 23%GRADE not reported 72 · 53.3%Very low 16 · 11.9%Low 8 · 5.9%Moderate 8 · 5.9%High 0 · 0%

Silver diamine fluoride (SDF) vs Fluoride varnish

Dental pain or sensitivity · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes dental pain or sensitivity compared with fluoride varnish (very low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Fluoride varnish

Primary caries prevention · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with fluoride varnish (very low certainty).

3 findings from 1 review

Silver diamine fluoride (SDF) vs Fluoride varnish

Secondary prevention of caries · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

3 findings from 1 review

Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish

Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review

Silver diamine fluoride (SDF) vs Silver nitrate plus fluoride varnish

Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review

Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish

Caries arrest · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes caries arrest compared with glass ionomer cement (GIC) plus fluoride varnish (very low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Fluoride varnish

Caries arrest · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

3 findings from 1 review

Silver diamine fluoride (SDF) vs Silver nitrate plus fluoride varnish

Caries arrest · Children and adults (with or without carious lesions)

Silver diamine fluoride (SDF) showed no clear difference in caries arrest compared with silver nitrate plus fluoride varnish (low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Fluoride varnish

Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review

Slow-release fluoride devices vs Alternative fluoride therapy (topical fluoride: toothpaste, mouthrinse, gel, or varnish)

Outcome not reported · Children or adults

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Fluorosis (adverse effect; % of children with fluorotic teeth) · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
2 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Plaque and gingivitis scores · Children and adolescents aged 16 years or less
1 finding from 1 review

Fluoride gel combined with fluoride mouthrinse vs Fluoride gel

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride gel combined with fluoride mouthrinse showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride gel alone; GRADE not reported.

1 finding from 1 review