Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

78 questions · 79 findings · 19 reviews · Headline outcomes only

No studies found 5 · 6.3%GRADE not reported 2 · 2.5%Very low 27 · 34.2%Low 18 · 22.8%Moderate 17 · 21.5%High 10 · 12.7%

Intervention not reported

Death · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in death (low certainty).

1 finding from 1 review

Intervention not reported

Anticoagulants: events ‐ bleeding · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in anticoagulants: events ‐ bleeding (low certainty).

1 finding from 1 review

Intervention not reported

Anticoagulants: events ‐ thromboembolism · patients with leading to fewer clinical adverse events

It is very uncertain whether the intervention changes anticoagulants: events ‐ thromboembolism (very low certainty).

1 finding from 1 review

Intervention not reported

Insulin ‐ hypoglycaemia (< 60 mg/dL) · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in insulin ‐ hypoglycaemia (< 60 mg/dL) (low certainty).

1 finding from 1 review

Intervention not reported

Insulin ‐ severe hypoglycaemia (< 40 mg/dL) · patients with leading to fewer clinical adverse events

It is very uncertain whether the intervention changes insulin ‐ severe hypoglycaemia (< 40 mg/dL) (very low certainty).

1 finding from 1 review

Intervention not reported

Aminoglycoside antibiotics ‐ nephrotoxicity · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in aminoglycoside antibiotics ‐ nephrotoxicity (low certainty).

1 finding from 1 review

Dual vs one antiplatelet agent

Stroke, myocardial infarction, or vascular death · preventing early recurrence after ischaemic stroke or TIA

Dual probably leads to lower stroke, myocardial infarction, or vascular death compared with one antiplatelet agent (moderate certainty).

1 finding from 1 review