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What do systematic reviews say?

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Evidence found and GRADE certainty

67 questions · 68 findings · 7 reviews · Headline outcomes only

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No studies found 27 · 39.7%GRADE not reported 3 · 4.4%Very low 0 · 0%Low 9 · 13.2%Moderate 14 · 20.6%High 15 · 22.1%

Intervention not reported

Reduction in disability score Health Assessment Questionnaire. Scale from: 0 to 3 · participants with rheumatoid arthritis and with a partial response to DMARDs
1 finding from 1 review

Intervention not reported

Radiographic progression Total Sharp Score Scale from: 0 to 448 · participants with rheumatoid arthritis and with a partial response to DMARDs
1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in withdrawals due to adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in serious adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious infections · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in serious infections (high certainty).

1 finding from 1 review

Intervention not reported

ACR50 American College of Rheumatology improvement criteria · participants with rheumatoid arthritis and with partial response to MTX

The intervention probably leads to higher ACR50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review

Intervention not reported

Remission Disease activity score < 2.6 · participants with rheumatoid arthritis and with partial response to MTX
1 finding from 1 review