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What do systematic reviews say?

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Evidence found and GRADE certainty

70 questions · 70 findings · 15 reviews · Headline outcomes only

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No studies found 23 · 32.9%GRADE not reported 2 · 2.9%Very low 18 · 25.7%Low 16 · 22.9%Moderate 9 · 12.9%High 2 · 2.9%

Summary of findings table ‐ Corticosteroids plus standard care vs placebo or usual care

All‐cause mortality up to 120 days · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19

It is very uncertain whether summary of findings table ‐ Corticosteroids plus standard care changes all‐cause mortality up to 120 days compared with standard care (plus/minus placebo) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Corticosteroids plus standard care vs placebo or usual care

Clinical improvement: discharged alive ( · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19

Summary of findings table ‐ Corticosteroids plus standard care may leads to higher clinical improvement: discharged alive ( compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Corticosteroids plus standard care vs placebo or usual care

Clinical worsening: new need for invasive mechanical ventilation or death · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19

Summary of findings table ‐ Corticosteroids plus standard care showed no clear difference in clinical worsening: new need for invasive mechanical ventilation or… compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Modified personal protective equipment (PPE): mask plus tabs vs standard masks

Contamination of mask from hands · healthcare workers

It is very uncertain whether modified personal protective equipment (PPE): mask plus tabs changes contamination of mask from hands compared with standard masks (very low certainty).

1 finding from 1 review

Modified personal protective equipment (PPE): mask plus tabs vs standard masks

Contamination of head from hands · healthcare workers

It is very uncertain whether modified personal protective equipment (PPE): mask plus tabs changes contamination of head from hands compared with standard masks (very low certainty).

1 finding from 1 review

Comparison #3: Decision coaching plus evidence‐based information vs evidence‐based information ‐ Summary of findings

Knowledge

It is very uncertain whether comparison #4: Decision coaching plus evidence‐based information changes knowledge tests: Standardised on score from 0 to 100 (none to… compared with evidence‐based information ‐ Summary of findings (very low certainty).

1 finding from 1 review