Rate of exacerbations with ED visit or hospitalisations Eosinophilic phenotype · patients with chronic obstructive pulmonary disease
Mepolizumab 100 mg showed no clear difference in rate of exacerbations with ED visit or hospitalisations Eosinophilic… compared with placebo (moderate certainty).
1 finding from 1 review
Rate of exacerbations requiring emergency department treatment or admission · patients with chronic obstructive pulmonary disease
Mepolizumab 100 mg showed no clear difference in rate of exacerbations with ED visit or hospitalisations All… compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · patients with chronic obstructive pulmonary disease
Mepolizumab 100 mg showed no clear difference in serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review
QoL · patients with chronic obstructive pulmonary disease
1 finding from 1 review
Change in SGRQ total score · patients with chronic obstructive pulmonary disease
1 finding from 1 review
Hospitalisations for COPD/100 patient‐years (action plan + phone · acute exacerbations of chronic obstructive pulmonary disease
Action plan showed no clear difference in hospitalisations for COPD/100 patient‐years (action plan + phone compared with usual care (moderate certainty).
1 finding from 1 review
Hospitalisations and emergency visits for COPD/100 patient‐years (action plan + phone · acute exacerbations of chronic obstructive pulmonary disease
Action plan leads to lower hospitalisations and emergency visits for COPD/100 patient‐years… compared with usual care (high certainty).
1 finding from 1 review
Hospital admissions · acute exacerbations of chronic obstructive pulmonary disease
Action plan probably leads to lower at least 1 hospital admission compared with usual care (moderate certainty).
1 finding from 1 review
Mortality (all‐cause) · acute exacerbations of chronic obstructive pulmonary disease
Action plan showed no clear difference in mortality (all‐cause) compared with usual care (moderate certainty).
1 finding from 1 review
Courses of oral corticosteroids · acute exacerbations of chronic obstructive pulmonary disease
1 finding from 1 review
Number of courses of antibiotics · acute exacerbations of chronic obstructive pulmonary disease
1 finding from 1 review
Quality of life St George's Respiratory Questionnaire (SGRQ) score · acute exacerbations of chronic obstructive pulmonary disease
1 finding from 1 review
Depression score · acute exacerbations of chronic obstructive pulmonary disease
1 finding from 1 review
Intervention not reported
Number of exacerbations of bronchiectasis Frequency of acute exacerbations of bronchiectasis · individuals with stable bronchiectasis
The intervention showed no clear difference in number of exacerbations of bronchiectasis Frequency of acute… (low certainty).
1 finding from 1 review
Intervention not reported
Hospitalisations · individuals with stable bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Health‐related quality of life (disease‐specific) Scale from 0 to 100; lower score indicates better HRQoL. SGRQ total score consists of weighted scores from 3 domains · individuals with stable bronchiectasis
1 finding from 1 review
Intervention not reported
Health‐related quality of life (cough‐specific) Leicester Cough Questionnaire Scale from 0 to 133; higher score indicates better HRQoL. Contains 19 questions from 3 domains on a Likert scale · individuals with stable bronchiectasis
1 finding from 1 review
Intervention not reported
Health‐related quality of life (health status) COPD Assessment Tool. Scale from 0 to 5; higher score indicates worse HRQoL Contains 10 questions with 5‐point Likert scale · individuals with stable bronchiectasis
The intervention showed no clear difference in health‐related quality of life (health status) COPD Assessment Tool.… (low certainty).
1 finding from 1 review
Intervention not reported
Respiratory symptoms (symptoms) Breathlessness, Cough and Sputum Scale Scale from 0 to 12. Lower score indicates fewer symptoms · individuals with stable bronchiectasis
The intervention showed no clear difference in respiratory symptoms (symptoms) Breathlessness, Cough and Sputum… (low certainty).
1 finding from 1 review
Intervention not reported
Adverse events (AEs) · individuals with stable bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found