Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

71 questions · 84 findings · 10 reviews · Dental caries

No studies found 8 · 9.5%GRADE not reported 63 · 75%Very low 6 · 7.1%Low 5 · 6%Moderate 2 · 2.4%High 0 · 0%

Fluoride-containing dental care products (mainly fluoride toothpaste; one study also included fluoride varnish) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total daily fluoride intake (TDFI) · Humans using fluoride-containing dental care products; 28 included studies, mostly young children, only two studies in adults (aged…

Fluoride-containing dental care products (mainly toothpaste) contributed on average 38% (SD 27%) of total daily fluoride intake, regardless of tap-water fluoride level or age (ungraded; descriptive synthesis, no meta-analysis).

1 finding from 1 review

Fluoride-containing dental care products (mainly fluoride toothpaste) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total fluoride exposure · Pregnant and lactating women

No study has explored the contribution of dental care products to total fluoride exposure in pregnant and lactating women.

1 finding from 1 review

Sealing (resin sealant, glass ionomer cement, or polyurethane tape) vs Non-invasive / control treatment

Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition)

Sealing probably reduces the odds of proximal lesion progression compared with placebo (OR 0.27, 95% CI 0.18 to 0.42; moderate certainty).

1 finding from 1 review