Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

81 questions · 95 findings · 6 reviews

No studies found 25 · 26.3%GRADE not reported 1 · 1.1%Very low 21 · 22.1%Low 39 · 41.1%Moderate 9 · 9.5%High 0 · 0%

DDAVP vs tranexamic acid (control)

All thrombotic events (including myocardial infarction, ischaemic stroke, other arterial thromboembolism, and venous thromboembolism) · participants undergoing surgery

It is very uncertain whether DDAVP changes all thrombotic events (including myocardial infarction, ischaemic… compared with tranexamic acid (very low certainty).

1 finding from 1 review

DDAVP vs placebo or usual care

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

DDAVP showed no clear difference in number of participants receiving a red cell transfusion (total) compared with placebo or standard care (moderate certainty).

1 finding from 1 review

DDAVP vs aprotinin

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

DDAVP may leads to higher number of participants receiving a red cell transfusion (total) compared with aprotinin (low certainty).

1 finding from 1 review

DDAVP vs placebo or usual care

Number of participants receiving a red cell transfusion (total) · participants with platelet dysfunction undergoing surgery

DDAVP showed no clear difference in number of participants receiving a red cell transfusion (total) compared with placebo or standard care: platelet dysfunction subgroup (low certainty).

1 finding from 1 review