Findings

What do systematic reviews say?

63 questions · 64 findings · 4 reviews · Kidney and Transplant

No studies found 5 · 7.8%GRADE not reported 0 · 0%Very low 15 · 23.4%Low 40 · 62.5%Moderate 4 · 6.3%High 0 · 0%

Complete remission · idiopathic steroid‐resistant nephrotic syndrome in children

Tacrolimus showed no clear difference in treatment response at 12 months: complete remission compared with cyclosporin (low certainty).

1 finding from 1 review

Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
RR 0.8 [0.45, 1.42]
2 studies · 58 participants
Low

Adverse events: persistent nephrotoxicity · idiopathic steroid‐resistant nephrotic syndrome in children

Tacrolimus showed no clear difference in adverse events: persistent nephrotoxicity compared with cyclosporin (low certainty).

1 finding from 1 review

Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
RR 0.48 [0.05, 4.85]
1 study · 41 participants
Low

Adverse events: worsening of hypertension · idiopathic steroid‐resistant nephrotic syndrome in children

1 finding from 1 review

Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 58 participants
Low