Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,187 questions · 1,233 findings · 137 reviews

No studies found 190 · 15.4%GRADE not reported 57 · 4.6%Very low 241 · 19.5%Low 323 · 26.2%Moderate 315 · 25.5%High 107 · 8.7%

Corticosteroids vs placebo

Improvement in sensory nerve function at 1 year · people with nerve damage (< 6 months' duration) in leprosy

Corticosteroids showed no clear difference in improvement in sensory nerve function at 1 year Defined as a… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Change in nerve pain and in nerve tenderness at 1 year ‐ not reported · people with nerve damage (6 to 24 months' duration) in leprosy

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids vs placebo

Adverse effects requiring withdrawal/discontinuation of study medication · people with nerve damage (6 to 24 months' duration) in leprosy

Corticosteroids showed no clear difference in adverse events Assessed as adverse events requiring withdrawal of… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Adverse events Assessed as: occurrence of one or more major adverse events requiring withdrawal of treatment · people with nerve damage (< 6 months' duration) in leprosy

Corticosteroids showed no clear difference in adverse events Assessed as: occurrence of one or more major adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Improvement in sensory nerve function at 1 year · people with nerve damage (6 to 24 months' duration) in leprosy

Corticosteroids showed no clear difference in improvement in sensory nerve function at 1 year compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Caloric extent of recovery (improvement as a % in lateralisation of electronystagmography on caloric testing) · Patients with idiopathic acute vestibular dysfunction (vestibular neuritis)
2 findings from 1 review

Corticosteroids vs placebo

Complete caloric recovery · Patients with idiopathic acute vestibular dysfunction (vestibular neuritis)

Corticosteroids may leads to higher complete caloric recovery compared with placebo (low certainty).

2 findings from 1 review

Systemic or topical corticosteroids vs placebo or control

Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (low certainty).

1 finding from 1 review