Findings

What do systematic reviews say?

69 questions · 69 findings · 4 reviews · Common Mental Disorders

No studies found 3 · 4.3%GRADE not reported 3 · 4.3%Very low 28 · 40.6%Low 13 · 18.8%Moderate 20 · 29%High 2 · 2.9%

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 661 participants
Moderate

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with citalopram (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.87 [0.6, 1.27]
3 studies · 732 participants
Moderate

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with citalopram (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.87 [0.48, 1.56]
3 studies · 732 participants
Moderate

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with citalopram (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.64 [0.34, 1.2]
3 studies · 732 participants
Moderate

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine showed no clear difference in failure to respond (reduction ≥ 50% on HDRS) compared with escitalopram (low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.02 [0.56, 1.85]
1 study · 240 participants
Low

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 231 participants
Low

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with escitalopram (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.53 [1, 2.37]
2 studies · 578 participants
Moderate

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with escitalopram (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.74 [0.46, 6.53]
2 studies · 578 participants
Moderate

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with escitalopram (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.17 [0.64, 2.12]
2 studies · 578 participants
Moderate