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Evidence found and GRADE certainty

62 questions · 64 findings · 4 reviews

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No studies found 4 · 6.3%GRADE not reported 17 · 26.6%Very low 21 · 32.8%Low 20 · 31.3%Moderate 2 · 3.1%High 0 · 0%

Lamotrigine vs lithium

Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder

Lamotrigine showed no clear difference in recurrence of any episodes at one year for clinical worsening with… compared with lithium (moderate certainty).

1 finding from 1 review

Lamotrigine vs placebo

Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder

Lamotrigine probably leads to lower recurrence of any episodes at one year for clinical worsening with… compared with placebo (moderate certainty).

1 finding from 1 review