Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

119 questions · 127 findings · 15 reviews · Developmental, Psychosocial and Learning Problems

No studies found 23 · 18.1%GRADE not reported 8 · 6.3%Very low 28 · 22%Low 57 · 44.9%Moderate 11 · 8.7%High 0 · 0%

Atypical antipsychotics vs placebo

Adverse effects (AEs) · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

Atypical antipsychotics may leads to higher adverse effects (AEs) compared with placebo (low certainty).

1 finding from 1 review

Neurohormones vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

It is very uncertain whether neurohormones changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Memantine vs placebo

Adverse effects sufficient to stop treatment · Children aged 6 to 18 years with ASD

Memantine showed no clear difference in adverse effects Assessed by the study authors as those that were… compared with placebo (low certainty).

1 finding from 1 review