Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

83 questions · 93 findings · 8 reviews

No studies found 7 · 7.5%GRADE not reported 13 · 14%Very low 5 · 5.4%Low 47 · 50.5%Moderate 21 · 22.6%High 0 · 0%

Interleukin‐2 RA induction vs monoclonal antibody induction

Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients

Interleukin‐2 RA induction showed no clear difference in acute rejection Acute rejection grade 3A or more verified by biopsy compared with monoclonal antibody induction (low certainty).

1 finding from 1 review

Interleukin‐2 RA induction vs monoclonal antibody induction

Infection Number of participants diagnosed with infection · heart transplant recipients

Interleukin‐2 RA induction showed no clear difference in infection Number of participants diagnosed with infection compared with monoclonal antibody induction (low certainty).

1 finding from 1 review

Interleukin‐2 RA induction vs monoclonal antibody induction

Post‐transplantation lymphoproliferative disorder Number of participants diagnosed with PTLD · heart transplant recipients

Interleukin‐2 RA induction showed no clear difference in post‐transplantation lymphoproliferative disorder Number of… compared with monoclonal antibody induction (low certainty).

1 finding from 1 review

Interleukin‐2 RA vs polyclonal antibody induction

Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients

Interleukin‐2 RA may leads to higher acute rejection Acute rejection grade 3A or more verified by biopsy compared with polyclonal antibody induction (low certainty).

1 finding from 1 review

Interleukin‐2 RA vs no induction

Post‐transplantation lymphoproliferative disorder Number of participants diagnosed with PTLD · heart transplant recipients

Interleukin‐2 RA showed no clear difference in post‐transplantation lymphoproliferative disorder Number of… compared with no induction (low certainty).

1 finding from 1 review

Intervention not reported

Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients

The intervention showed no clear difference in acute rejection Acute rejection grade 3A or more verified by biopsy (low certainty).

1 finding from 1 review

Intervention not reported

Infection Number of participants diagnosed with infection · heart transplant recipients

The intervention showed no clear difference in infection Number of participants diagnosed with infection (low certainty).

1 finding from 1 review

Intervention not reported

Cytomegalovirus infection Number of patients diagnosed with CMV infection · heart transplant recipients

The intervention showed no clear difference in cytomegalovirus infection Number of patients diagnosed with CMV… (low certainty).

1 finding from 1 review

Intervention not reported

Post‐transplantation lymphoproliferative disorder Number of participants diagnosed with PTLD · heart transplant recipients

The intervention showed no clear difference in post‐transplantation lymphoproliferative disorder Number of… (low certainty).

1 finding from 1 review

Intervention not reported

Cancer Number of participants diagnosed with cancer · heart transplant recipients

The intervention showed no clear difference in cancer Number of participants diagnosed with cancer (low certainty).

1 finding from 1 review