What do systematic reviews say?

Oral vs intravenous acetylcysteine

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 66 participants
  Very low

Oral vs intravenous acetylcysteine

The review found no eligible studies for this question.

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral vs intravenous acetylcysteine

It is very uncertain whether oral changes nausea compared with intravenous acetylcysteine (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 2.71 [1, 7.38]
  1 study · 66 participants
  Very low

Oral vs intravenous acetylcysteine

It is very uncertain whether oral changes vomiting compared with intravenous acetylcysteine (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 2.1 [0.62, 7.12]
  1 study · 66 participants
  Very low

Intravenous acetylcysteine vs placebo

Intravenous acetylcysteine may leads to lower mortality compared with placebo (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.29 [0.09, 0.94]
  1 study · 50 participants
  Low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 180 participants
  Very low

Methionine and supportive treatment vs supportive treatment

Methionine and supportive treatment may leads to lower hepatotoxicity compared with supportive treatment (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.05 [0.01, 0.53]
  1 study · 26 participants
  Low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

It is very uncertain whether initial infusion rate of intravenous acetylcysteine over 15 minutes changes hepatotoxicity compared with 60 minutes (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 1.34 [0.39, 4.56]
  1 study · 175 participants
  Very low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

Initial infusion rate of intravenous acetylcysteine over 15 minutes may leads to lower any adverse event compared with 60 minutes (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.51 [0.27, 0.96]
  1 study · 180 participants
  Low

Oral plus intravenous acetylcysteine vs intravenous acetylcysteine

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Oral plus intravenous acetylcysteine vs intravenous acetylcysteine

The review found no eligible studies for this question.

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Charcoal haemoperfusion vs no intervention

It is very uncertain whether charcoal haemoperfusion changes mortality compared with no intervention (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 7.39 [0.15, 372.38]
  1 study · 16 participants
  Very low

Cysteamine vs no intervention

It is very uncertain whether cysteamine changes mortality compared with no intervention (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.53 [0.05, 5.22]
  2 studies · 65 participants
  Very low

Cysteamine vs no intervention

Cysteamine may leads to lower hepatotoxicity (aspartate aminotransferase > 1000 IU/L) compared with no intervention (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.09 [0.02, 0.35]
  2 studies · 65 participants
  Low

Cysteamine vs dimercaprol

It is very uncertain whether cysteamine changes mortality compared with dimercaprol (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.14 [0, 6.82]
  1 study · 52 participants
  Very low

Cysteamine vs dimercaprol

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 52 participants
  Low

Cysteamine vs methionine (randomised trials)

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Very low

Cysteamine vs methionine (randomised trials)

It is very uncertain whether cysteamine changes hepatotoxicity (aspartate aminotransferase > 1000 U/L) compared with methionine (randomised trials) (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.92 [0.05, 16.46]
  1 study · 27 participants
  Very low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 222 participants
  Very low

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  6 hours postdosing · Ibuprofen 400 mg vs paracetamol 1000 mg
  RR 1.47 [1.28, 1.69]
  5 studies · 646 participants
  High