Pulmonary exacerbations · children aged 7 years or over and adults with cystic fibrosis
Summary of findings: liprotamase showed no clear difference in pulmonary exacerbations: number of exacerbations compared with porcine PERT (low certainty).
1 finding from 1 review
Adverse events · adults with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Pulmonary exacerbations · adults with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in weight (kg) · adults and children with cystic fibrosis
It is very uncertain whether summary of findings: ECM changes change in weight (kg) compared with ECT (very low certainty).
1 finding from 1 review
Change in height · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Major bleeding · CRRT
Citrate probably leads to lower major bleeding compared with unfractionated heparin (moderate certainty).
1 finding from 1 review
Successful prevention of clotting · CRRT
It is very uncertain whether unfractionated heparin changes successful prevention of clotting compared with low molecular weight heparin (very low certainty).
1 finding from 1 review
Treatment cessation due to adverse events · CRRT
Unfractionated heparin showed no clear difference in treatment cessation due to adverse events compared with low molecular weight heparin (low certainty).
1 finding from 1 review
Recovery of kidney function · CRRT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Thrombocytopenia · CRRT
It is very uncertain whether unfractionated heparin changes thrombocytopenia compared with low molecular weight heparin (very low certainty).
1 finding from 1 review
Cost to health care services · CRRT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Major bleeding · CRRT
It is very uncertain whether unfractionated heparin changes major bleeding compared with no pharmacological anticoagulation (very low certainty).
1 finding from 1 review
Death at 28 days · CRRT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Successful prevention of clotting · CRRT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment cessation due to adverse events · CRRT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recovery of kidney function · CRRT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Death at 28 days · CRRT
Citrate showed no clear difference in death at 28 days compared with unfractionated heparin (moderate certainty).
1 finding from 1 review
Thrombocytopenia · CRRT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cost to health care services · CRRT
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Successful prevention of clotting · CRRT
Citrate probably leads to higher successful prevention of clotting compared with unfractionated heparin (moderate certainty).
1 finding from 1 review