Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,257 questions · 1,337 findings · 183 reviews

No studies found 175 · 13.1%GRADE not reported 212 · 15.9%Very low 286 · 21.4%Low 341 · 25.5%Moderate 254 · 19%High 69 · 5.2%

Statins plus beta interferon vs interferon beta‐1a

Relapse · Multiple sclerosis

It is very uncertain whether statins plus beta interferon changes number of participants with relapses at 12 months Number of… compared with beta interferon (very low certainty).

2 findings from 1 review

Statins plus beta interferon vs interferon beta‐1a

Number of participants with progression at 24 months Number of participants with progression at 24 months · Multiple sclerosis

It is very uncertain whether statins plus beta interferon changes number of participants with progression at 24 months Number of… compared with beta interferon (very low certainty).

1 finding from 1 review

Statins plus beta interferon vs interferon beta‐1a

Number of participants with new T2 or GELs at 12 months Number of participants with new T2 or GELs at 12 months · Multiple sclerosis

It is very uncertain whether statins plus beta interferon changes number of participants with new T2 or GELs at 12 months Number of… compared with beta interferon (very low certainty).

1 finding from 1 review

Glatiramer acetate vs placebo

Patients who progressed ‐ at 2 years · people with multiple sclerosis

Glatiramer acetate showed no clear difference in patients who progressed ‐ at 2 years compared with placebo; GRADE not reported.

2 findings from 1 review

Intervention not reported

Patients with progression of the disease ( · patients with Primary Progressive Multiple Sclerosis

The intervention showed no clear difference in patients with progression of the disease ( (high certainty).

1 finding from 1 review

Intervention not reported

Patients with severe adverse event ( · patients with Primary Progressive Multiple Sclerosis

The intervention showed no clear difference in patients with severe adverse event ( (high certainty).

1 finding from 1 review

Intervention not reported

Patients with any related adverse event ( · patients with Primary Progressive Multiple Sclerosis

The intervention leads to higher patients with any related adverse event ( (high certainty).

1 finding from 1 review

Intervention not reported

Sustained increase in spasticity ( · patients with Primary Progressive Multiple Sclerosis

The intervention showed no clear difference in sustained increase in spasticity ( (high certainty).

1 finding from 1 review