What do systematic reviews say?

First‐line low‐dose thiazide vs placebo

• First‐line drugs for hypertension 2018 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 8870 participants
  Low

Summary of findings: low‐dose vs high‐dose PERT

• Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low

Summary of findings: low‐dose vs high‐dose PERT

The review found no eligible studies for this question.

• Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: low‐dose vs high‐dose PERT

The review found no eligible studies for this question.

• Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: low‐dose vs high‐dose PERT

• Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low

Summary of findings: low‐dose vs high‐dose PERT

• Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low

Summary of findings: low‐dose vs high‐dose PERT

• Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 146 participants
  Very low

Summary of findings: low‐dose vs high‐dose PERT

The review found no eligible studies for this question.

• Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low‐level laser therapy vs Conventional orthodontic appliance treatment

It is very uncertain whether low level laser therapy (LLLT) changes rate of orthodontic tooth movement during space closure stage… compared with conventional orthodontic appliance treatment (very low certainty).

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes

  Space closure stage
  MD 0.18 [0.10, 0.26]
  1 study · 45 participants
  Very low

Low‐level laser therapy vs Conventional orthodontic appliance treatment

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
  SoF states harms/side effects Not reported; Ghaffer 2022 (the only LLLT study to assess harms) reported no serious harms other than gingivitis associated with plaque accumulation.
  1 study
  GRADE not reported

Low‐level laser therapy vs Conventional orthodontic appliance treatment

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
  Abellan 2021 assessed periodontal health (plaque index, pocket depth, bleeding on probing) after intrusion of maxillary molars; no evidence of significant difference with LLLT. Statistical test results not published.
  1 study
  GRADE not reported

Low‐level laser therapy vs Conventional orthodontic appliance treatment

It is very uncertain whether low level laser therapy (LLLT) changes total number of orthodontic appliance adjustment appointments during… compared with conventional orthodontic appliance treatment (very low certainty).

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes

  Alignment stage
  MD -2.25 [-2.52, -1.97]
  2 studies · 125 participants
  Very low

Low‐level laser therapy vs Conventional orthodontic appliance treatment

It is very uncertain whether low level laser therapy (LLLT) changes patient perception of pain and discomfort (VAS 0 to 100 mm) compared with conventional orthodontic appliance treatment (very low certainty).

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes

  Space closure / first visit
  MD -0.4 [-1.87, 1.07]
  1 study · 37 participants
  Very low

Low‐level laser therapy vs Conventional orthodontic appliance treatment

It is very uncertain whether low level laser therapy (LLLT) changes duration of orthodontic treatment during alignment stage compared with conventional orthodontic appliance treatment (very low certainty).

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes

  Alignment stage
  MD -48.87 [-56.48, -41.26]
  3 studies · 92 participants
  Very low

Low‐level laser therapy vs Conventional orthodontic appliance treatment

The review found no eligible studies for this question.

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
  Patient-reported need for analgesics | Not reported
  Studies not reported
  No studies found

Low‐level laser therapy vs Conventional orthodontic appliance treatment

The review found no eligible studies for this question.

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
  No study reported on the influence of LLLT on the total number of orthodontic appliance adjustment visits to complete a course of treatment.
  Studies not reported
  No studies found

Low‐level laser therapy vs Conventional orthodontic appliance treatment

The review found no eligible studies for this question.

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
  No study reported on the influence of LLLT on the total overall orthodontic treatment duration.
  Studies not reported
  No studies found

Low‐level laser therapy vs Conventional orthodontic appliance treatment

It is very uncertain whether low level laser therapy (LLLT) changes rate of orthodontic tooth movement during alignment stage… compared with conventional orthodontic appliance treatment (very low certainty).

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes

  First month of alignment (also second month)
  MD 1.63 [-2.60, 5.86]
  2 studies · 56 participants
  Very low

Low‐level laser therapy vs Conventional orthodontic appliance treatment

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes

  3 and 6 months
  Two studies (62 participants), not pooled. Abellan 2021: no significant difference in molar intrusion at 3 months (1.25 vs 1.72 mm) or 6 months (1.09 vs 1.28 mm), nor rate per month. Hasan 2022: increased intrusion…
  2 studies · 62 participants
  GRADE not reported

Low‐level laser therapy vs Conventional orthodontic appliance treatment

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
  Abellan 2021 assessed OIIRR using CBCT after intrusion of maxillary molars; no evidence of significant increase or reduction with LLLT. Statistical test results not published.
  1 study
  GRADE not reported