What do systematic reviews say?

Intraperitoneal vs oral calcitriol

Intraperitoneal showed no clear difference in abnormal bone histology Bone biopsy compared with oral calcitriol (low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 1.06 [0.7, 1.61]
  1 study · 33 participants
  Low

Intermittent oral vs oral calcitriol

Intermittent oral showed no clear difference in fall in PTH compared with daily oral calcitriol (moderate certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 0.88 [0.65, 1.19]
  1 study · 59 participants
  Moderate
• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 83 participants
  Moderate

Intermittent oral vs oral calcitriol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 83 participants
  Moderate

Intermittent oral vs oral calcitriol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 80 participants
  Moderate

Intermittent oral vs oral calcitriol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Low

Vitamin D vs placebo/no treatment

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 12 participants
  Low

Vitamin D vs placebo/no treatment

Vitamin D preparations may leads to lower number without 30% fall in PTH on two occasions compared with placebo/no treatment (low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 0.6 [0.4, 0.89]
  2 studies · 76 participants
  Low

Vitamin D vs placebo/no treatment

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 103 participants
  Low

Vitamin D vs placebo/no treatment

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 76 participants
  Moderate

Calcitriol vs ergocalciferol

It is very uncertain whether calcitriol changes height velocity equal to or greater than expected compared with ergocalciferol (very low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 0.22 [0.03, 1.53]
  1 study · 15 participants
  Very low

Calcitriol vs ergocalciferol

It is very uncertain whether calcitriol changes improved bone histology compared with ergocalciferol (very low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 1.53 [0.77, 3.06]
  1 study · 15 participants
  Very low

Intraperitoneal vs oral calcitriol

Intraperitoneal showed no clear difference in adynamic bone disease Bone histology compared with oral calcitriol (low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 1.49 [0.59, 3.74]
  1 study · 33 participants
  Low

Calcitriol vs ergocalciferol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 13 participants
  Very low

Calcitriol vs ergocalciferol

It is very uncertain whether calcitriol changes hypercalcaemia compared with ergocalciferol (very low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 1.75 [0.68, 4.5]
  1 study · 15 participants
  Very low

Calcitriol vs ergocalciferol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 13 participants
  Very low

Calcitriol vs ergocalciferol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 13 participants
  Very low

Calcitriol vs ergocalciferol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 13 participants
  Very low

Calcium carbonate vs aluminium hydroxide

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low

Calcium carbonate vs aluminium hydroxide

It is very uncertain whether calcium carbonate changes abnormal bone biopsy Bone histology compared with aluminium hydroxide (very low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 0.35 [0.13, 0.95]
  1 study · 17 participants
  Very low

Calcium carbonate vs aluminium hydroxide

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low