Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,138 questions · 1,154 findings · 139 reviews · Headline outcomes only

No studies found 184 · 15.9%GRADE not reported 183 · 15.9%Very low 273 · 23.7%Low 296 · 25.6%Moderate 171 · 14.8%High 47 · 4.1%

Intervention not reported

Long‐term sequelae · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

SJS/TEN (Stevens‐Johnson syndrome/toxic epidermal necrolysis) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

AGEP (acute generalised exanthematous pustulosis) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

HSS (hypersensitivity) reaction including SJS/TEN (clinically diagnosed) (6 weeks clinical assessment) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The intervention probably leads to lower HSS (hypersensitivity) reaction including SJS/TEN (clinically… (moderate certainty).

1 finding from 1 review

Intervention not reported

HSS reaction including SJS/TEN (immunologically confirmed) (6 weeks clinical assessment) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The intervention probably leads to lower HSS reaction including SJS/TEN (immunologically confirmed) (6 weeks… (moderate certainty).

1 finding from 1 review

Intervention not reported

Death · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Multi‐systemic therapy involving family and juveniles vs treatment

Arrested · drug‐using offenders with co‐occurring mental health problems

Multi‐systemic therapy involving family and juveniles showed no clear difference in arrested assessed by corroborating with police data compared with treatment (low certainty).

1 finding from 1 review

Switch to another antipsychotic vs antipsychotic cessation

Adverse effects: use of antiparkinsonism drugs · psychiatric patients (schizophrenia) with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether switch to another antipsychotic changes adverse effects: use of antiparkinsonism drugs compared with antipsychotic cessation (very low certainty).

1 finding from 1 review

Brief intervention vs treatment

Decreased alcohol use · concurrent problem alcohol and illicit drug users

Brief intervention (BI) showed no clear difference in decreased alcohol use compared with treatment (low certainty).

2 findings from 1 review

Motivational interviewing vs treatment

Over 50% less standard drinks per day Timeline follow back · concurrent problem alcohol and illicit drug users

Motivational interviewing (MI) showed no clear difference in greater than 50% reduction in number of standard drinks consumed per… compared with treatment (low certainty).

1 finding from 1 review

Motivational interviewing vs treatment

Abstinence from alcohol over the last 30 days · concurrent problem alcohol and illicit drug users

Motivational interviewing (MI) showed no clear difference in abstinence from alcohol over the last 30 days compared with treatment (low certainty).

1 finding from 1 review