Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

781 questions · 1,089 findings · 92 reviews · Dental caries

No studies found 77 · 7.1%GRADE not reported 781 · 71.7%Very low 86 · 7.9%Low 97 · 8.9%Moderate 38 · 3.5%High 10 · 0.9%

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

Interdental brushing plus toothbrushing may leads to lower gingivitis (bleeding and gingival indices; standardised across… compared with flossing plus toothbrushing (low certainty).

2 findings from 1 review · compare the 2 reviews

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Change in oral health knowledge and skills · Children aged 4 to 12 years attending primary school
1 finding from 1 review

Fluoride varnish vs placebo or no treatment

Adverse effects / specific side effects (oral allergic reactions, mucosal irritation, adverse symptoms such as nausea, gagging, vomiting) · Children and adolescents aged 16 years or less
1 finding from 1 review

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Plaque · Adults, 16 years and older (dentate)

Interdental brushing plus toothbrushing showed no clear difference in plaque (plaque indices; standardised across indices) compared with flossing plus toothbrushing (low certainty).

2 findings from 1 review · compare the 2 reviews

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Changes in dental attendance · Children aged 4 to 12 years attending primary school
1 finding from 1 review

Interdental brushing plus toothbrushing vs Toothbrushing alone

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether interdental brushing plus toothbrushing changes gingivitis (Loe-Silness gingival index, interproximal; scale 0 to 4) compared with toothbrushing alone (very low certainty).

1 finding from 1 review · compare the 2 reviews

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Behavioural outcomes (reported and/or other measures, e.g. data tracking toothbrushes and collecting food wrappers) · Children aged 4 to 12 years attending primary school

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride varnish vs placebo or no treatment

Proportion of children developing new caries (permanent) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in proportion of children developing one or more new caries (permanent… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Frequency of cariogenic food and drink consumption · Children aged 4 to 12 years attending primary school
1 finding from 1 review

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review · compare the 2 reviews