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What do systematic reviews say?

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Evidence found and GRADE certainty

749 questions · 769 findings · 63 reviews · Headline outcomes only

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No studies found 202 · 26.3%GRADE not reported 31 · 4%Very low 172 · 22.4%Low 211 · 27.4%Moderate 106 · 13.8%High 47 · 6.1%

Lidocaine vs tocainide

Adverse events (AEs) (1 or more events) · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): any adverse event compared with tocainide (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

All‐cause mortality · patients with myocardial infarction

It is very uncertain whether lidocaine changes all‐cause mortality compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

Cardiac mortality · patients with myocardial infarction

It is very uncertain whether lidocaine changes cardiac mortality compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

Ventricular fibrillation · patients with myocardial infarction

It is very uncertain whether lidocaine changes ventricular fibrillation compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

Adverse events (AEs; adverse drug reaction): atrioventricular block · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): atrioventricular block compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

Adverse events (AEs; adverse drug reaction): composite neurological adverse event (confusion, vertigo, nystagmus, vomiting and diplopia) · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): composite neurological… compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Ventricular fibrillation · patients with myocardial infarction

It is very uncertain whether lidocaine changes ventricular fibrillation compared with propafenone (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Adverse events (AEs; adverse drug reaction): heart failure · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): heart failure compared with propafenone (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Adverse events (AEs; adverse drug reaction): bilateral bundle branch block · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): bilateral bundle branch… compared with propafenone (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Neuropsychiatric adverse event · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): neuropsychiatric… compared with propafenone (very low certainty).

1 finding from 1 review