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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Taxane‐containing chemotherapy vs any chemotherapy without taxane

Neuropathy (including grade 3/4 sensory or motor neuropathy, or both) · women with early breast cancer

Taxane‐containing chemotherapy probably leads to higher neuropathy (including grade 3/4 sensory or motor neuropathy, or both) compared with any chemotherapy without taxane (moderate certainty).

1 finding from 1 review

Taxane‐containing chemotherapy vs any chemotherapy without taxane

Cardiotoxicity (including grade 3/4 and congestive cardiac failure) · women with early breast cancer

Taxane‐containing chemotherapy showed no clear difference in cardiotoxicity (including grade 3/4 and congestive cardiac failure) compared with any chemotherapy without taxane (moderate certainty).

1 finding from 1 review