Findings

What do systematic reviews say?

4,783 questions · 10,022 findings · 882 reviews

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No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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PACK‐CXL with standard therapy vs Standard therapy alone (radiotherapy or chemoradiotherapy)

Proportion of participants with reduction in intraocular inflammation at 4 to 8 weeks Assessed by corneal keratic precipitates, anterior chamber cellular reaction, or other appropriate measure · participants of any age with confirmed cases of bacterial keratitis

1 finding from 1 review

Corneal collagen cross‐linking for bacterial infectious keratitis 2020 · Cochrane Headline outcomes only
no estimate extracted
0 participants
GRADE not reported

PACK‐CXL with standard therapy vs Standard therapy alone (radiotherapy or chemoradiotherapy)

Proportion of participants with treatment failure at 4 to 8 weeks Assessed by outcome assessors · participants of any age with confirmed cases of bacterial keratitis

1 finding from 1 review

Corneal collagen cross‐linking for bacterial infectious keratitis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Low

PACK‐CXL with standard therapy vs Standard therapy alone (radiotherapy or chemoradiotherapy)

Proportion of participants with adverse events at 4 to 8 weeks Assessed by outcome assessors · participants of any age with confirmed cases of bacterial keratitis

1 finding from 1 review

Corneal collagen cross‐linking for bacterial infectious keratitis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Low

Taxane‐containing chemotherapy vs any chemotherapy without taxane

Overall survival · women with early breast cancer

Taxane‐containing chemotherapy leads to lower overall survival compared with any chemotherapy without taxane (high certainty).

1 finding from 1 review

Taxanes for adjuvant treatment of early breast cancer 2019 · Cochrane Headline outcomes only
HR 0.87 [0.83, 0.92]
27 studies · 39180 participants
High

Taxane‐containing chemotherapy vs any chemotherapy without taxane

Disease‐free progression · women with early breast cancer

Taxane‐containing chemotherapy leads to lower disease‐free progression compared with any chemotherapy without taxane (high certainty).

1 finding from 1 review

Taxanes for adjuvant treatment of early breast cancer 2019 · Cochrane Headline outcomes only
HR 0.88 [0.85, 0.92]
29 studies · 41909 participants
High

Taxane‐containing chemotherapy vs any chemotherapy without taxane

Quality of life · women with early breast cancer

1 finding from 1 review

Taxanes for adjuvant treatment of early breast cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 7 participants
Low

Taxane‐containing chemotherapy vs any chemotherapy without taxane

Febrile neutropenia · women with early breast cancer

Taxane‐containing chemotherapy showed no clear difference in febrile neutropenia compared with any chemotherapy without taxane (moderate certainty).

1 finding from 1 review

Taxanes for adjuvant treatment of early breast cancer 2019 · Cochrane Headline outcomes only
OR 1.43 [0.89, 2.31]
23 studies · 34154 participants
Moderate

Taxane‐containing chemotherapy vs any chemotherapy without taxane

Neuropathy (including grade 3/4 sensory or motor neuropathy, or both) · women with early breast cancer

Taxane‐containing chemotherapy probably leads to higher neuropathy (including grade 3/4 sensory or motor neuropathy, or both) compared with any chemotherapy without taxane (moderate certainty).

1 finding from 1 review

Taxanes for adjuvant treatment of early breast cancer 2019 · Cochrane Headline outcomes only
OR 6.89 [3.23, 14.71]
22 studies · 31033 participants
Moderate

Taxane‐containing chemotherapy vs any chemotherapy without taxane

Cardiotoxicity (including grade 3/4 and congestive cardiac failure) · women with early breast cancer

Taxane‐containing chemotherapy showed no clear difference in cardiotoxicity (including grade 3/4 and congestive cardiac failure) compared with any chemotherapy without taxane (moderate certainty).

1 finding from 1 review

Taxanes for adjuvant treatment of early breast cancer 2019 · Cochrane Headline outcomes only
OR 0.87 [0.56, 1.33]
23 studies · 32894 participants
Moderate

Low‐level laser therapy vs Low-level laser therapy (LLLT) + calcium hydroxide

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
No clinical failure in any participant (Fernandes 2015); not estimable
1 study · 30 participants
GRADE not reported

Low‐level laser therapy vs Low-level laser therapy (LLLT) + calcium hydroxide

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Low-level laser therapy (LLLT) showed no clear difference in radiological failure compared with low-level laser therapy (LLLT) + calcium hydroxide; GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.00 [0.24, 4.18]
1 study · 30 participants
GRADE not reported

Occupational therapy vs usual care

BADL (primary outcome) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Occupational therapy vs usual care

5a. Visual attention overall (postintervention) · adults with cognitive impairment after stroke

2 findings from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 620 participants
Low
Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 293 participants
Low

Occupational therapy vs usual care

5c. Sustained visual attention (postintervention) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 463 participants
Moderate

Occupational therapy vs usual care

Memory (specific cognitive function) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
6 participants
GRADE not reported

Occupational therapy vs usual care

Cognitive subdomain: working memory measured at the end of · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 420 participants
Low

Occupational therapy vs usual care

6b. Immediate verbal memory span (postintervention) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 357 participants
Very low

Occupational therapy vs usual care

6c. Immediate spatial memory span (postintervention) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 292 participants
Low

Occupational therapy vs usual care

Executive function (specific cognitive function) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
7 participants
GRADE not reported

Occupational therapy vs usual care

7a. Executive functional performance overall (postintervention) · adults with cognitive impairment after stroke

1 finding from 1 review

Occupational therapy for cognitive impairment in stroke patients 2022 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 550 participants
Very low