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Evidence found and GRADE certainty

1,057 questions · 1,077 findings · 32 reviews · Skin

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No studies found 395 · 36.7%GRADE not reported 89 · 8.3%Very low 172 · 16%Low 177 · 16.4%Moderate 191 · 17.7%High 53 · 4.9%

Chemical peeling vs combined chemical peeling plus any active intervention

Participant‐assessed adverse events (short‐term) N of participants with adverse events · people with acne scars

It is very uncertain whether chemical peeling changes participant‐assessed adverse events (short‐term) N of participants… compared with combined chemical peeling plus any active intervention (very low certainty).

1 finding from 1 review

Fractional laser vs non‐fractional non‐ablative laser

Adverse events ‐ hyperpigmentation ( · people with acne scars

It is very uncertain whether fractional laser changes investigator‐assessed adverse events (short‐term) Hyperpigmentation… compared with non‐fractional non‐ablative laser (very low certainty).

1 finding from 1 review

Chemical peeling vs needling

Participant‐reported scar improvement (long‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Chemical peeling vs needling

Participant‐reported scar improvement (short‐term) N of participants with > 50% improvement in acne scars · people with acne scars

It is very uncertain whether chemical peeling changes participant‐reported scar improvement (short‐term) N of participants… compared with needling (very low certainty).

1 finding from 1 review

Chemical peeling vs needling

Investigator‐assessed adverse events (short‐term) · people with acne scars

Chemical peeling showed no clear difference in investigator‐assessed adverse events (short‐term) N of participants… compared with needling (low certainty).

1 finding from 1 review

Chemical peeling vs needling

Participant‐assessed adverse events (short‐term) N of participants with positive adverse events · people with acne scars

It is very uncertain whether chemical peeling changes participant‐assessed adverse events (short‐term) N of participants… compared with needling (very low certainty).

1 finding from 1 review

Chemical peeling vs needling

Patient satisfaction Number of satisfied patients · people with acne scars

It is very uncertain whether chemical peeling changes patient satisfaction N of satisfied participants compared with needling (very low certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Participant‐reported scar improvement (short‐term) N of participants with > 50% improvement in acne scars · people with acne scars

Injectable fillers probably leads to higher participant‐reported scar improvement (short‐term) N of participants… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Fractional laser vs non‐fractional non‐ablative laser

Participant‐assessed adverse events (short‐term) Burning N of participants with adverse events · people with acne scars

It is very uncertain whether fractional laser changes participant‐assessed adverse events (short‐term) Burning N of… compared with non‐fractional non‐ablative laser (very low certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Patient satisfaction Number of satisfied patients · people with acne scars

Injectable fillers probably leads to higher participant satisfaction N of satisfied participants compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Participant‐assessed adverse events (short‐term) N of participants with positive adverse events · people with acne scars

Injectable fillers showed no clear difference in participant‐reported adverse events (short‐term) N of participants… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Investigator‐assessed adverse events (short‐term) N of participants with positive adverse events · people with acne scars

Injectable fillers showed no clear difference in investigator‐assessed adverse events (short‐term) N of participants… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Fractional laser vs radiofrequency

Participant‐reported scar improvement (long‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review