Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,338 questions · 2,104 findings · 136 reviews · Dental caries

No studies found 159 · 7.6%GRADE not reported 1,657 · 78.8%Very low 138 · 6.6%Low 111 · 5.3%Moderate 36 · 1.7%High 3 · 0.1%

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Further conventional dental treatment (filling and drilling) (binary yes/no) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review
  • Data were not provided by any study on the number of lesions requiring restorations to 6 months or later; no data on any further conventional treatment or other dental interventions.
    Studies not reported
    No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Caries progression/regression (clinical severity index, log(e) ECM and log(e) DIAGNOdent scores) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…
1 finding from 1 review
  • Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
    6 and 12 months
    No consistent trend of benefit or harm following ozone was seen across the outcome measures in any of the three studies; analyses were conducted at the lesion level (not independent of the person), so data were not…
    3 studies · 137 participants
    GRADE not reported

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected Significant Caries (SiC) index · Alaska Native children (below age 18)

A simulation projected a 50% drop in the Significant Caries index for children (12.3 to 6.1) under the PDHA model (certainty not graded).

2 findings from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected proportion of caries-free children (5-18 years) · Alaska Native children (below age 18)

A simulation projected 0% of children aged 5-18 would be caries-free under the baseline scenario (certainty not graded).

3 findings from 1 review

Dental imaging (analog or digital radiographs) vs Visual classification

Difference in sensitivity · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)

Imaging had lower sensitivity than visual classification in the fully within-person analysis.

1 finding from 1 review

Dental imaging (analog or digital radiographs) vs Visual classification

Difference in specificity · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)

Imaging and visual classification had similar specificity in the fully within-person analysis.

1 finding from 1 review

Dental fillings (restorations) vs No treatment

Outcome not reported · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free

The review found no eligible studies for this question.

1 finding from 1 review

Interdental brushing plus toothbrushing vs Toothbrushing alone

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether interdental brushing plus toothbrushing changes gingivitis (gingival index) compared with toothbrushing alone (very low certainty).

3 findings from 2 reviews · compare the 2 reviews

Interdental brushing plus toothbrushing vs Toothbrushing alone

Plaque · Adults, 16 years and older (dentate)

Interdental brushing plus toothbrushing may leads to lower plaque compared with toothbrushing alone (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

Interdental brushing plus toothbrushing may leads to lower gingivitis (proportion of bleeding sites) compared with flossing plus toothbrushing (low certainty).

4 findings from 2 reviews · compare the 2 reviews
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Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Plaque · Adults, 16 years and older (dentate)

It is very uncertain whether interdental brushing plus toothbrushing changes plaque compared with flossing plus toothbrushing (very low certainty).

3 findings from 2 reviews · compare the 2 reviews

Interdental brushing plus toothbrushing vs Toothbrushing alone

Side effects · Adults, 16 years and older (dentate)
2 findings from 2 reviews · compare the 2 reviews

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Side effects · Adults, 16 years and older (dentate)
2 findings from 2 reviews · compare the 2 reviews

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Periodontitis (probing pocket depth) · Adults, 16 years and older (dentate)

Interdental brushing plus toothbrushing showed no clear difference in periodontitis (probing pocket depth) compared with flossing plus toothbrushing (low certainty).

1 finding from 1 review